Postdoc
position available to study protein aggregation and turnover in neurodegeneration
The aim of this project is to discover novel pathways of protein
degradation in conformational dementias. The collaborative project will profit
from the expertise of the Glatzel lab (pathophysiology
of neurodegeneration) and the Hoppe lab (protein degradation using Caenorhabditis
elegans as a model organism). The Postdoc
will be a part of the newly founded research unit "Neuronal Protein
Turnover" at the University Medical Center Hamburg Eppendorf and the
Centre for Molecular Neurobiology in
Selected Literature:
Accumulation of mutant neuroserpin
precedes development of clinical symptoms in familial encephalopathy with neuroserpin inclusion bodies. Galliciotti G., Glatzel
M., Kinter J., Kozlov S.V., Cinelli P., Rülicke T., Sonderegger P. (2007). Accumulation of mutant neuroserpin precedes
development of clinical symptoms in familial encephalopathy with neuroserpin inclusion bodies. Am J Pathol. 2007 Apr;170(4): 1305-13.
The ubiquitin-selective chaperone CDC-48/p97 links
myosin assembly to human myopathy. Janiesch P.C., Kim J., Mouysset
J., Barikbin R., Lochmüller
H., Cassata G., Krause S., and Hoppe T. (2007). Nat. Cell Biol. Apr;9(4): 379-90.
The UNC-45 Chaperone Mediates Sarcomere Assembly
through Myosin Degradation in C. elegans. Landsverk
M.L., Hutagalung A.H., Li S., Najafov
A., Hoppe T., Barral J.M., and Epstein H.F. (2007). J.
Cell Biol. 23;177(2): 205-10.
To apply, please forward curriculum vitae,
bibliography, and the names and addresses of referees to:
Prof. Dr.
or Dr. Thorsten
Hoppe (Centre for Molecular Neurobiology