We are starting a new C. elegans group in Rennes (Britanny, France), focusing on the physiological role of membrane traffic during development. In particular, we examine the function of the AP-1 adaptor complex which is involved in several routes of post-Golgi trafficking and in epithelial cell polarity. The function of this complex is especially investigated during embryogenesis and vulva formation. We are also exploiting a genome-wide RNAi screen during which we identified several new AP-1 genetic interactors; the function of these candidates and the nature of their interaction with AP-1 is to be investigated in the context of membrane traffic during C. elegans development.

Our team is funded by an INSERM Avenir grant. We can offer post-doctoral salaries, but candidates will also be encouraged to apply for their own fellowship (to the Région Bretagne and french/international organisations). The team belongs to the UMR 6061 Génétique et Développement (http://www.umr6061.univ-rennes1.fr/english/equipes/) where several groups work at the interface between cell biology and development on various models. The quality of in-house equipment is excellent, from confocal and video microscopy to microarrays and sequencing facilities. The unit is situated in Rennes, a very nice city in Brittany, close to the seaside and world-renowned Mont Saint Michel.

Training in cell or developmental biology is required and prior experience with C. elegans and/or electron microscopy is desirable but not essential. French speaking is not required. Please send a CV, a list of publications and the name of 2/3 referees to:

Grégoire Michaux

UMR 6061

Faculté de Médecine

2 avenue du Professeur Léon Bernard

CS 34317

F-35043 Rennes Cedex

France

Tel: +33 -2 23 23 47 75

Email: gregoire.michaux@univ-rennes1.fr

Website: http://umr6061.univ-rennes1.fr/english/equipes/fichiers_equipe/Michaux_MSTMCE_en.html