POSTDOCTORAL FELLOW/RESEARCH ASSOCIATE POSITIONS AT VANDERBILT UNIVERSITY SCHOOL OF MEDICINE

Postdoctoral fellow/research associate positions are available immediately at Vanderbilt University School of Medicine for scientists with a broad interest in the integrative/systems physiology of membrane solute and water transport and epithelial cell signaling. Our laboratory utilizes a multidisciplinary approach including patch clamp electrophysiology, quantitative cellular imaging, molecular biology, protein chemistry, computer modeling, reverse and forward genetic analysis, and cell genomic and proteomic profiling to investigate ClC ion channel regulation and structure/function, IP₃–dependent oscillatory calcium signaling and osmotic stress signaling in the genetically tractable model organism C. elegans. Possible projects include:

· Molecular/structural mechanisms of phosphorylation-dependent ClC anion channel gating

· Role of CBS domains in regulating ClC voltage and extracellular ion sensitivity

· Role of TRPM channels in epithelial cell oscillatory Ca²⁺ signaling

· Mechanisms of TRPM channel regulation

· Role of PDZ proteins in formation of macromolecular calcium signaling complexes

· Characterization of upstream signaling components of an evolutionarily conserved osmosensitive Ste20 kinase cascade

Candidates should have or be close to obtaining a Ph.D. in physiology, zoology or a related discipline. Please send your curriculum vitae and the names and addresses of three references to:

Dr. Kevin Strange

Vanderbilt University Medical Center

T-4202 Medical Center North

1161 21^st Avenue South

Nashville, TN 37232-2520

Email: kevin.strange@vanderbilt.edu

FAX: 615-343-3916

Qualified individuals will be invited to Vanderbilt to meet with members of the laboratory and our colleagues and collaborators.